1XR7

Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16

Replaces:  1TE9

Summary for 1XR7

• Entry DOI: 10.2210/pdb1xr7/pdb
• Related: 1TE8 1TE9 1TEB 1XR5 1XR6
• Descriptor: Genome polyprotein (2 entities in total)
• Functional Keywords: rna-dependent rna polymerase, transferase
• Biological source: Human rhinovirus 16
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): Q82122
• Total number of polymer chains: 2
• Total formula weight: 104572.00

Authors

Love, R.A.,Maegley, K.A.,Yu, X.,Ferre, R.A.,Lingardo, L.K.,Diehl, W.,Parge, H.E.,Dragovich, P.S.,Fuhrman, S.A. (deposition date: 2004-10-13, release date: 2004-10-26, Last modification date: 2024-02-14)

• Primary citation: Love, R.A.,Maegley, K.A.,Yu, X.,Ferre, R.A.,Lingardo, L.K.,Diehl, W.,Parge, H.E.,Dragovich, P.S.,Fuhrman, S.A.; The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy; Structure, 12:1533-1544, 2004; PubMed: 15296746; DOI: 10.1016/j.str.2004.05.024

Experimental method

X-RAY DIFFRACTION (2.3 Å)