1XQG
3.10 A crystal structure of maspin, Space group P 4 21 2
Summary for 1XQG
| Entry DOI | 10.2210/pdb1xqg/pdb |
| Related | 1XQJ |
| Descriptor | Maspin (2 entities in total) |
| Functional Keywords | serpin, maspin, tumor suppression, antitumor protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted, extracellular space: P36952 |
| Total number of polymer chains | 2 |
| Total formula weight | 87551.10 |
| Authors | Al-Ayyoubi, M.,Gettins, P.G.,Volz, K. (deposition date: 2004-10-12, release date: 2004-10-26, Last modification date: 2023-08-23) |
| Primary citation | Al-Ayyoubi, M.,Gettins, P.G.,Volz, K. Crystal Structure of Human Maspin, a Serpin with Antitumor Properties: Reactive Center Loop of Mapsin is Exposed but Constrained J.Biol.Chem., 279:55540-55544, 2004 Cited by PubMed Abstract: Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors. PubMed: 15501821DOI: 10.1074/jbc.M409957200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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