1XNN

CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH (3A-ALPHA-,4-ALPHA 7-ALPHA-,7A-ALPHA-)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE.

1XNN の概要

• エントリーDOI: 10.2210/pdb1xnn/pdb
• 分子名称: Androgen receptor, REL-(3AR,4S,7R,7AS)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE (3 entities in total)
• 機能のキーワード: androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Nucleus: P15207
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30602.76

構造登録者

Sack, J. (登録日: 2004-10-05, 公開日: 2005-10-11, 最終更新日: 2023-08-23)

• 主引用文献: Salvati, M.E.,Balog, A.,Shan, W.,Wei, D.D.,Pickering, D.,Attar, R.M.,Geng, J.,Rizzo, C.A.,Gottardis, M.M.,Weinmann, R.,Krystek, S.R.,Sack, J.,An, Y.,Kish, K.; Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.; Bioorg.Med.Chem.Lett., 15:271-276, 2005; PubMed: 15603938; DOI: 10.1016/j.bmcl.2004.10.085

実験手法

X-RAY DIFFRACTION (2.2 Å)