1XN2

New substrate binding pockets for beta-secretase.

Summary for 1XN2

• Entry DOI: 10.2210/pdb1xn2/pdb
• Related: 1FKN 1M4H 1SGZ 1XN3
• Descriptor: Beta-secretase 1, OM03-4 (3 entities in total)
• Functional Keywords: beta secretase, memapsin2, bace, asp2, aspartic protease, alzheimer's disease, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 8
• Total formula weight: 179806.41

Authors

Turner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J. (deposition date: 2004-10-04, release date: 2005-03-22, Last modification date: 2023-11-15)

• Primary citation: Turner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J.; Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).; Biochemistry, 44:105-112, 2005; PubMed: 15628850; DOI: 10.1021/bi048106k

Experimental method

X-RAY DIFFRACTION (1.9 Å)