1XM9

Structure of the armadillo repeat domain of plakophilin 1

Summary for 1XM9

• Entry DOI: 10.2210/pdb1xm9/pdb
• Descriptor: plakophilin 1 (1 entity in total)
• Functional Keywords: armadillo repeat, cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus. Nucleus: Q13835
• Total number of polymer chains: 1
• Total formula weight: 50489.10

Authors

Choi, H.J.,Weis, W.I. (deposition date: 2004-10-01, release date: 2005-03-22, Last modification date: 2024-02-14)

Primary citation

Choi, H.J.,Weis, W.I.
Structure of the armadillo repeat domain of plakophilin 1.
J.Mol.Biol., 346:367-376, 2005

PubMed Abstract: The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.

PubMed: 15663951
DOI: 10.1016/j.jmb.2004.11.048

Experimental method

X-RAY DIFFRACTION (2.8 Å)