1XL5

HIV-1 Protease in complex with amidhyroxysulfone

Summary for 1XL5

Entry DOI	10.2210/pdb1xl5/pdb
Related	1AJX 1HVI 1XL2
Descriptor	PROTEASE RETROPEPSIN, CHLORIDE ION, N-{(1S)-1-(3-BROMOBENZYL)-4-[(4-BROMOPHENYL)SULFONYL]-6-METHYL-2-OXOHEPTYL}-2-(2,6-DIMETHYLPHENOXY)ACETAMIDE, ... (4 entities in total)
Functional Keywords	aspartyl protease, hiv protease, amidhydroxysulfone inhibitor, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22348.47
Authors	Boettcher, J.,Specker, E.,Heine, A.,Klebe, G. (deposition date: 2004-09-30, release date: 2005-06-07, Last modification date: 2023-08-23)
Primary citation	Specker, E.,Boettcher, J.,Lilie, H.,Heine, A.,Schoop, A.,Muller, G.,Griebenow, N.,Klebe, G. An Old Target Revisited: Two New Privileged Skeletons and an Unexpected Binding Mode For HIV-Protease Inhibitors Angew.Chem.Int.Ed.Engl., 44:3140-3144, 2005 Cited by PubMed: 15822136 DOI: 10.1002/anie.200462643 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation