1XL0

Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole,-benzothiazole, and-benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.

Summary for 1XL0

Related1P4J 1P4H 1P4G 1K06 1XKX 1XL1
DescriptorGlycogen phosphorylase, muscle form, 2-(BETA-D-GLUCOPYRANOSYL)-5-METHYL-1,3,4-OXADIAZOLE, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
Functional Keywordsglycogenolysis, type 2 diabetes, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains1
Total molecular weight97784.56
Authors
Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G. (deposition date: 2004-09-30, release date: 2005-03-15, Last modification date: 2011-07-13)
Primary citation
Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G.
Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site
Protein Sci., 14:873-888, 2005
PubMed: 15741340 (PDB entries with the same primary citation)
DOI: 10.1110/ps.041216105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.92 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers70.1%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution