1XJB

Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules

1XJB の概要

• エントリーDOI: 10.2210/pdb1xjb/pdb
• 分子名称: Aldo-keto reductase family 1 member C2, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total)
• 機能のキーワード: human 3alphahds3; aldo-keto reductase; nadp; induce-fit mecanism, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76163.19

構造登録者

Couture, J.-F.,Pereira de Jesus-Tran, K.,Roy, A.-M.,Legrand, P.,Cantin, L.,Cote, P.-L.,Luu-The, V.,Labrie, F.,Breton, R. (登録日: 2004-09-23, 公開日: 2005-06-21, 最終更新日: 2023-08-23)

• 主引用文献: Couture, J.-F.,Roy, A.-M.,Cantin, L.,Legrand, P.,Luu-The, V.,Labrie, F.,Breton, R.; Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen; Protein Sci., 14:1485-1497, 2005; PubMed: 15929998; DOI: 10.1110/ps.051353205

実験手法

X-RAY DIFFRACTION (1.9 Å)