Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1XE3

Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis

Summary for 1XE3
Entry DOI10.2210/pdb1xe3/pdb
Descriptorpurine nucleoside phosphorylase, CHLORIDE ION (3 entities in total)
Functional Keywordspurine nucleoside phosphorylase, deod, spine, structural genomics, structural proteomics in europe, transferase
Biological sourceBacillus anthracis
Total number of polymer chains6
Total formula weight161562.71
Authors
Grenha, R.,Levdikov, V.M.,Fogg, M.,Blagova, E.V.,Brannigan, J.A.,Wilkinson, A.J.,Wilson, K.S.,Structural Proteomics in Europe (SPINE) (deposition date: 2004-09-09, release date: 2004-10-26, Last modification date: 2023-08-23)
Primary citationGrenha, R.,Levdikov, V.M.,Fogg, M.J.,Blagova, E.V.,Brannigan, J.A.,Wilkinson, A.J.,Wilson, K.S.
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.
Acta Crystallogr.,Sect.F, 61:459-462, 2005
Cited by
PubMed Abstract: Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
PubMed: 16511068
DOI: 10.1107/S174430910501095X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.24 Å)
Structure validation

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon