1XCS

structure of oligonucleotide/drug complex

Summary for 1XCS

Descriptor5'-D(*CP*GP*TP*AP*CP*G)-3', COBALT (II) ION, 9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM, ... (5 entities in total)
Functional Keywordsdrug-dna complex, double helix, co2+, dna
Total number of polymer chains2
Total molecular weight4801.22
Authors
Valls, N.,Steiner, R.A.,Wright, G.,Murshudov, G.N.,Subirana, J.A. (deposition date: 2004-09-03, release date: 2005-07-19, Last modification date: 2011-11-16)
Primary citation
Valls, N.,Steiner, R.A.,Wright, G.,Murshudov, G.N.,Subirana, J.A.
Variable role of ions in two drug intercalation complexes of DNA
J.Biol.Inorg.Chem., 10:476-482, 2005
PubMed: 15926069 (PDB entries with the same primary citation)
DOI: 10.1007/s00775-005-0655-3
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.4 Å)
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Structure validation

RfreeClashscoreRSRZ outliers0.257108.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1xcs
no rotation
Molmil generated image of 1xcs
rotated about x axis by 90°
Molmil generated image of 1xcs
rotated about y axis by 90°