1XCG

Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF

Summary for 1XCG

Entry DOI	10.2210/pdb1xcg/pdb
Descriptor	Rho guanine nucleotide exchange factor 11, Transforming protein RhoA (3 entities in total)
Functional Keywords	x-ray crystallography; regulation of rhoa gtpase; protein complex, signaling protein activator-signaling protein complex, signaling protein activator/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: O15085 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains	4
Total formula weight	125875.00
Authors	Derewenda, U.,Oleksy, A.,Stevenson, A.S.,Korczynska, J.,Dauter, Z.,Somlyo, A.P.,Otlewski, J.,Somlyo, A.V.,Derewenda, Z.S. (deposition date: 2004-09-01, release date: 2004-12-14, Last modification date: 2024-02-14)
Primary citation	Derewenda, U.,Oleksy, A.,Stevenson, A.S.,Korczynska, J.,Dauter, Z.,Somlyo, A.P.,Otlewski, J.,Somlyo, A.V.,Derewenda, Z.S. The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle Structure, 12:1955-1965, 2004 Cited by PubMed: 15530360 DOI: 10.1016/j.str.2004.09.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation