1XBC

Crystal structure of the syk tyrosine kinase domain with Staurosporin

Summary for 1XBC

Entry DOI	10.2210/pdb1xbc/pdb
Related	1XBA 1XBB
Descriptor	Tyrosine-protein kinase SYK, STAUROSPORINE (3 entities in total)
Functional Keywords	staurosporine, syk, spleen typrosine kinase, active conformation, structural genomics, structural genomix, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34350.54
Authors	Badger, J.,Atwell, S.,Adams, J.M.,Buchanan, M.D.,Feil, I.K.,Froning, K.J.,Gao, X.,Hendle, J.,Keegan, K.,Leon, B.C.,Muller-Deickmann, H.J.,Nienaber, V.L.,Noland, B.W.,Post, K.,Rajashankar, K.R.,Ramos, A.,Russell, M.,Burley, S.K.,Buchanan, S.G. (deposition date: 2004-08-30, release date: 2004-11-02, Last modification date: 2024-02-14)
Primary citation	Atwell, S.,Adams, J.M.,Badger, J.,Buchanan, M.D.,Feil, I.K.,Froning, K.J.,Gao, X.,Hendle, J.,Keegan, K.,Leon, B.C.,Muller-Deickmann, H.J.,Nienaber, V.L.,Noland, B.W.,Post, K.,Rajashankar, K.R.,Ramos, A.,Russell, M.,Burley, S.K.,Buchanan, S.G. A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase J.Biol.Chem., 279:55827-55832, 2004 Cited by PubMed: 15507431 DOI: 10.1074/jbc.M409792200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation