1XBB

Crystal structure of the syk tyrosine kinase domain with Gleevec

1XBB の概要

• エントリーDOI: 10.2210/pdb1xbb/pdb
• 関連するPDBエントリー: 1XBA 1XBC
• 分子名称: Tyrosine-protein kinase SYK, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
• 機能のキーワード: gleevec, sti-571, imatinib, syk, spleen typrosine kinase, active conformation, structural genomics, structural genomix, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34377.61

構造登録者

Nienaber, V.L.,Atwell, S.,Adams, J.M.,Badger, J.,Buchanan, M.D.,Feil, I.K.,Froning, K.J.,Gao, X.,Hendle, J.,Keegan, K.,Leon, B.C.,Muller-Deickmann, H.J.,Noland, B.W.,Post, K.,Rajashankar, K.R.,Ramos, A.,Russell, M.,Burley, S.K.,Buchanan, S.G. (登録日: 2004-08-30, 公開日: 2004-11-02, 最終更新日: 2024-02-14)

• 主引用文献: Atwell, S.,Adams, J.M.,Badger, J.,Buchanan, M.D.,Feil, I.K.,Froning, K.J.,Gao, X.,Hendle, J.,Keegan, K.,Leon, B.C.,Muller-Deickmann, H.J.,Nienaber, V.L.,Noland, B.W.,Post, K.,Rajashankar, K.R.,Ramos, A.,Russell, M.,Burley, S.K.,Buchanan, S.G.; A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase; J.Biol.Chem., 279:55827-55832, 2004; PubMed: 15507431; DOI: 10.1074/jbc.M409792200

実験手法

X-RAY DIFFRACTION (1.57 Å)