1XA5
Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
Summary for 1XA5
Entry DOI | 10.2210/pdb1xa5/pdb |
Descriptor | Calmodulin, CALCIUM ION, 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, 5"-SPIRO-OXAZOLIDINO-4-DEACETOXY-VINBLASTINE, ... (4 entities in total) |
Functional Keywords | calmodulin, vinca alkaloid, kar-2, drug binding, metal binding protein |
Biological source | Bos taurus (cattle) |
Total number of polymer chains | 1 |
Total formula weight | 17708.08 |
Authors | Horvath, I.,Harmat, V.,Hlavanda, E.,Naray-Szabo, G.,Ovadi, J. (deposition date: 2004-08-25, release date: 2004-12-21, Last modification date: 2023-10-25) |
Primary citation | Horvath, I.,Harmat, V.,Perczel, A.,Palfi, V.,Nyitrai, L.,Nagy, A.,Hlavanda, E.,Naray-Szabo, G.,Ovadi, J. The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug J.Biol.Chem., 280:8266-8274, 2005 Cited by PubMed: 15596444DOI: 10.1074/jbc.M410353200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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