1XA5

Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid

1XA5 の概要

• エントリーDOI: 10.2210/pdb1xa5/pdb
• 分子名称: Calmodulin, CALCIUM ION, 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, 5"-SPIRO-OXAZOLIDINO-4-DEACETOXY-VINBLASTINE, ... (4 entities in total)
• 機能のキーワード: calmodulin, vinca alkaloid, kar-2, drug binding, metal binding protein
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17708.08

構造登録者

Horvath, I.,Harmat, V.,Hlavanda, E.,Naray-Szabo, G.,Ovadi, J. (登録日: 2004-08-25, 公開日: 2004-12-21, 最終更新日: 2023-10-25)

• 主引用文献: Horvath, I.,Harmat, V.,Perczel, A.,Palfi, V.,Nyitrai, L.,Nagy, A.,Hlavanda, E.,Naray-Szabo, G.,Ovadi, J.; The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug; J.Biol.Chem., 280:8266-8274, 2005; PubMed: 15596444; DOI: 10.1074/jbc.M410353200

実験手法

X-RAY DIFFRACTION (2.12 Å)