1X96

Crystal structure of Aldose Reductase with citrates bound in the active site

1X96 の概要

• エントリーDOI: 10.2210/pdb1x96/pdb
• 関連するPDBエントリー: 1PWM 1X97 1X98
• 分子名称: aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (4 entities in total)
• 機能のキーワード: eight strandard alpha/beta barrel, active site, the c-terminal end of the barrel, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37025.99

構造登録者

El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A. (登録日: 2004-08-19, 公開日: 2004-09-07, 最終更新日: 2023-10-25)

• 主引用文献: El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A.; High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor; J.Med.Chem., 47:4530-4537, 2004; PubMed: 15317464; DOI: 10.1021/jm0497794

実験手法

X-RAY DIFFRACTION (1.4 Å)