1X95
Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)
Summary for 1X95
Entry DOI | 10.2210/pdb1x95/pdb |
Related | 2MG8 |
Descriptor | 5'-D(*AP*TP*GP*CP*AP*T)-3', 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM (2 entities in total) |
Functional Keywords | anticancer drug, transcription inhibition, novel dna binding, ap-1, mln944, dna |
Total number of polymer chains | 2 |
Total formula weight | 4207.18 |
Authors | Dai, J.,Punchihewa, C.,Mistry, P.,Ooi, A.T.,Yang, D. (deposition date: 2004-08-19, release date: 2004-09-28, Last modification date: 2014-09-17) |
Primary citation | Dai, J.,Punchihewa, C.,Mistry, P.,Ooi, A.T.,Yang, D. Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug. J.Biol.Chem., 279:46096-46103, 2004 Cited by PubMed: 15317822DOI: 10.1074/jbc.M404053200 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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