1X8B
Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
Summary for 1X8B
Entry DOI | 10.2210/pdb1x8b/pdb |
Descriptor | Wee1-like protein kinase, MAGNESIUM ION, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, ... (4 entities in total) |
Functional Keywords | kinase, cell cycle, wee1, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P30291 |
Total number of polymer chains | 1 |
Total formula weight | 32861.95 |
Authors | Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (deposition date: 2004-08-17, release date: 2005-06-07, Last modification date: 2024-03-13) |
Primary citation | Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation Structure, 13:541-550, 2005 Cited by PubMed: 15837193DOI: 10.1016/j.str.2004.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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