1X81

Farnesyl transferase structure of Jansen compound

1X81 の概要

関連するPDBエントリー1NI1
分子名称Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (4 entities in total)
機能のキーワードfanesyltransferase, transferase
由来する生物種Rattus norvegicus (Norway rat)
ポリマー鎖数2
分子量合計83062.4
構造登録者
Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L. (登録日: 2004-08-16, 公開日: 2004-12-21, 最終更新日: 2011-07-13)
主引用文献
Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L.
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14:5367-5370, 2004
PubMed: 15454228 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2004.08.012
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.5 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers363.5%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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