1X27

Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas

Summary for 1X27

• Entry DOI: 10.2210/pdb1x27/pdb
• Related: 1lck
• Descriptor: Proto-oncogene tyrosine-protein kinase LCK, CRK-associated substrate, SODIUM ION, ... (4 entities in total)
• Functional Keywords: lck-cas complex, lck phospho-peptide complex, high affinity lck-cas complex, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P06239; Cell junction, focal adhesion: Q63767
• Total number of polymer chains: 12
• Total formula weight: 121003.40

Authors

Nasertorabi, F.,Tars, K.,Becherer, K.,Kodandapani, R.,Liljas, L.,Vuori, K.,Ely, K.R. (deposition date: 2005-04-20, release date: 2006-02-07, Last modification date: 2023-11-15)

• Primary citation: Nasertorabi, F.,Tars, K.,Becherer, K.,Kodandapani, R.,Liljas, L.,Vuori, K.,Ely, K.R.; Molecular basis for regulation of Src by the docking protein p130Cas; J.MOL.RECOG., 19:30-38, 2006; PubMed: 16245368; DOI: 10.1002/jmr.755

Experimental method

X-RAY DIFFRACTION (2.7 Å)