1X26

Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone

Summary for 1X26

• Entry DOI: 10.2210/pdb1x26/pdb
• Descriptor: 5'-D(*CP*TP*AP*AP*CP*AP*GP*AP*AP*TP*G)-3', 5'-D(*CP*AP*TP*TP*CP*AP*GP*TP*TP*AP*G)-3', N~3~-{3-[(7-METHYL-1,8-NAPHTHYRIDIN-2-YL)AMINO]-3-OXOPROPYL}-N~1~-[(7-OXO-7,8-DIHYDRO-1,8-NAPHTHYRIDIN-2-YL)METHYL]-BET A-ALANINAMIDE (3 entities in total)
• Functional Keywords: dna, aa mismatch, drug
• Total number of polymer chains: 2
• Total formula weight: 7633.45

Authors

Nakatani, K.,Hagihara, S.,Goto, Y.,Kobori, A.,Hagihara, M.,Hayashi, G.,Kyo, M.,Nomura, M.,Mishima, M.,Kojima, C. (deposition date: 2005-04-20, release date: 2006-04-04, Last modification date: 2022-03-02)

• Primary citation: Nakatani, K.,Hagihara, S.,Goto, Y.,Kobori, A.,Hagihara, M.,Hayashi, G.,Kyo, M.,Nomura, M.,Mishima, M.,Kojima, C.; Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats; Nat.Chem.Biol., 1:39-43, 2005; PubMed: 16407992; DOI: 10.1038/nchembio708

Experimental method

SOLUTION NMR