1WUT

Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes

Summary for 1WUT

Entry DOI	10.2210/pdb1wut/pdb
Related	1C50 1WUY 1WV0 1WV1
Descriptor	Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, 7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC ACID, ... (4 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, transferase
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	98026.11
Authors	Klabunde, T.,Wendt, K.U.,Kadereit, D.,Brachvogel, V.,Burger, H.-J.,Herling, A.W.,Oikonomakos, N.G.,Kosmopoulou, M.N.,Schmoll, D.,Sarubbi, E.,von Roedern, E.,Schonafinger, K.,Defossa, E. (deposition date: 2004-12-08, release date: 2005-12-08, Last modification date: 2011-07-13)
Primary citation	Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Kostas, I.D.,Wendt, K.U.,Klabunde, T.,Defossa, E. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14:1760-1771, 2005 Cited by PubMed: 15987904 DOI: 10.1110/ps.051432405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation