1WUT

Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes

1WUT の概要

• エントリーDOI: 10.2210/pdb1wut/pdb
• 関連するPDBエントリー: 1C50 1WUY 1WV0 1WV1
• 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, 7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98026.11

構造登録者

Klabunde, T.,Wendt, K.U.,Kadereit, D.,Brachvogel, V.,Burger, H.-J.,Herling, A.W.,Oikonomakos, N.G.,Kosmopoulou, M.N.,Schmoll, D.,Sarubbi, E.,von Roedern, E.,Schonafinger, K.,Defossa, E. (登録日: 2004-12-08, 公開日: 2005-12-08, 最終更新日: 2011-07-13)

• 主引用文献: Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Kostas, I.D.,Wendt, K.U.,Klabunde, T.,Defossa, E.; Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs; Protein Sci., 14:1760-1771, 2005; PubMed: 15987904; DOI: 10.1110/ps.051432405

実験手法

X-RAY DIFFRACTION (2.26 Å)