1W96
Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Summary for 1W96
Entry DOI | 10.2210/pdb1w96/pdb |
Related | 1OD2 1OD4 1UYR 1UYS 1UYT 1UYV 1W2X 1W93 |
Descriptor | ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A (3 entities in total) |
Functional Keywords | ligase, obesity, diabetes, fatty acid metabolism, structure-based drug design, allosteric inhibition, polyketide |
Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 3 |
Total formula weight | 186519.02 |
Authors | Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. (deposition date: 2004-10-06, release date: 2005-01-04, Last modification date: 2024-05-08) |
Primary citation | Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product Mol.Cell, 16:881-, 2004 Cited by PubMed: 15610732DOI: 10.1016/J.MOLCEL.2004.11.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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