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1W93

Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae

Summary for 1W93
Entry DOI10.2210/pdb1w93/pdb
Related1OD2 1OD4 1UYR 1UYS 1UYT 1UYV 1W2X
DescriptorACETYL-COENZYME A CARBOXYLASE (2 entities in total)
Functional Keywordsobesity, diabetes, fatty acid metabolism, structure-based drug design, allosteric inhibition, polyketide, ligase
Biological sourceSACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular locationCytoplasm: Q00955
Total number of polymer chains1
Total formula weight61523.17
Authors
Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. (deposition date: 2004-10-05, release date: 2005-01-04, Last modification date: 2011-07-13)
Primary citationShen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L.
A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16:881-, 2004
Cited by
PubMed: 15610732
DOI: 10.1016/J.MOLCEL.2004.11.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

数据于2024-03-27公开中

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