1W72

Crystal structure of HLA-A1:MAGE-A1 in complex with Fab-Hyb3

1W72 の概要

• エントリーDOI: 10.2210/pdb1w72/pdb
• 関連するPDBエントリー: 1AO7 1BD2 1FO0 1G6R 1MWA 1OGA 2CKB
• 分子名称: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, MELANOMA-ASSOCIATED ANTIGEN 1, ... (7 entities in total)
• 機能のキーワード: immune system, hla/fab fragment, human leucocyte antigen, peptide-specific fab, tcr-like binding, mhc-i
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P30443; Secreted: P61769; Cytoplasm: P43355
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 182094.00

構造登録者

Hulsmeyer, M.,Chames, P.,Hillig, R.C.,Stanfield, R.L.,Held, G.,Coulie, P.G.,Alings, C.,Wille, G.,Saenger, W.,Uchanska-Ziegler, B.,Hoogenboom, H.R.,Ziegler, A. (登録日: 2004-08-27, 公開日: 2004-11-09, 最終更新日: 2023-12-13)

• 主引用文献: Hulsmeyer, M.,Chames, P.,Hillig, R.C.,Stanfield, R.L.,Held, G.,Coulie, P.G.,Alings, C.,Wille, G.,Saenger, W.,Uchanska-Ziegler, B.,Hoogenboom, H.R.,Ziegler, A.; A Major Histocompatibility Complex.Peptide- Restricted Antibody and T Cell Receptor Molecules Recognize Their Target by Distinct Binding Modes: Crystal Structure of Human Leukocyte Antigen (Hla)-A1.Mage-A1 in Complex with Fab-Hyb3; J.Biol.Chem., 280:2972-, 2005; PubMed: 15537658; DOI: 10.1074/JBC.M411323200

実験手法

X-RAY DIFFRACTION (2.15 Å)