1W6K

Structure of human OSC in complex with Lanosterol

Summary for 1W6K

• Entry DOI: 10.2210/pdb1w6k/pdb
• Related: 1W6J
• Descriptor: LANOSTEROL SYNTHASE, octyl beta-D-glucopyranoside, LANOSTEROL, ... (4 entities in total)
• Functional Keywords: cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P48449
• Total number of polymer chains: 1
• Total formula weight: 86158.29

Authors

Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Ruf, A. (deposition date: 2004-08-19, release date: 2004-10-29, Last modification date: 2020-07-29)

• Primary citation: Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Stihle, M.,Ruf, A.; Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase; Nature, 432:118-, 2004; PubMed: 15525992; DOI: 10.1038/NATURE02993

Experimental method

X-RAY DIFFRACTION (2.1 Å)