1W6K

Structure of human OSC in complex with Lanosterol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000250	molecular_function	lanosterol synthase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008610	biological_process	lipid biosynthetic process
A	0016020	cellular_component	membrane
A	0016104	biological_process	triterpenoid biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0016866	molecular_function	intramolecular transferase activity
A	0031647	biological_process	regulation of protein stability

Functional Information from PROSITE/UniProt

site_id	PS01074
Number of Residues	15
Details	TERPENE_SYNTHASES Terpene synthases signature. DGSWeGsWGVcFtYG

Chain	Residue	Details
A	ASP574-GLY588

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:15525992

Chain	Residue	Details
A	ASP455

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:15525992

Chain	Residue	Details
A	TRP387
A	PHE444
A	TRP581

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	THR2

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	GLY588

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	TYR704

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	PHE585

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