1W6K
Structure of human OSC in complex with Lanosterol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000250 | molecular_function | lanosterol synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016104 | biological_process | triterpenoid biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016866 | molecular_function | intramolecular transferase activity |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0033489 | biological_process | cholesterol biosynthetic process via desmosterol |
| A | 0033490 | biological_process | cholesterol biosynthetic process via lathosterol |
| A | 0036197 | biological_process | zymosterol biosynthetic process |
| A | 0098554 | cellular_component | cytoplasmic side of endoplasmic reticulum membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01074 |
| Number of Residues | 15 |
| Details | TERPENE_SYNTHASES Terpene synthases signature. DGSWeGsWGVcFtYG |
| Chain | Residue | Details |
| A | ASP574-GLY588 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"PFTB 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"PFTB 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"PFTB 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"PFTB 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"PFTB 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15525992","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"15525992","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | GLY588 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | TYR704 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | PHE585 |
