1W6J

Structure of human OSC in complex with Ro 48-8071

Summary for 1W6J

Entry DOI	10.2210/pdb1w6j/pdb
Descriptor	LANOSTEROL SYNTHASE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, octyl beta-D-glucopyranoside, ... (5 entities in total)
Functional Keywords	cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein : P48449
Total number of polymer chains	1
Total formula weight	84930.51
Authors	Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Ruf, A. (deposition date: 2004-08-18, release date: 2004-10-29, Last modification date: 2023-12-13)
Primary citation	Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Stihle, M.,Ruf, A. Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase Nature, 432:118-, 2004 Cited by PubMed: 15525992 DOI: 10.1038/NATURE02993 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation