1W45

The 2.5 Angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus.

1W45 の概要

• エントリーDOI: 10.2210/pdb1w45/pdb
• 関連するPDBエントリー: 1W3W
• 分子名称: ANNEXIN A8 (2 entities in total)
• 機能のキーワード: coagulation, annexin family, calcium and phospholipid binding proteins, intact n-terminus, cxalcium and membrane- binding protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73737.86

構造登録者

Rety, S.,Sopkova-de Oliveira Santos, J.,Raguenes-Nicol, C.,Dreyfuss, L.,Blondeau, K.,Hofbauerova, K.,Renouard, M.,Russo-Marie, F.,Lewit-Bentley, A. (登録日: 2004-07-22, 公開日: 2005-01-18, 最終更新日: 2024-10-16)

主引用文献

Rety, S.,Sopkova-De Oliveira Santos, J.,Dreyfuss, L.,Blondeau, K.,Hofbauerova, K.,Raguenes-Nicol, C.,Kerboeuf, D.,Renouard, M.,Russo-Marie, F.,Lewit-Bentley, A.
The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
J.Mol.Biol., 345:1131-, 2005

PubMed Abstract: Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.

PubMed: 15644210
DOI: 10.1016/J.JMB.2004.11.015

実験手法

X-RAY DIFFRACTION (2.51 Å)