1W0C

Inhibition of Leishmania major pteridine reductase (PTR1) by 2,4,6-triaminoquinazoline; structure of the NADP ternary complex.

1W0C の概要

• エントリーDOI: 10.2210/pdb1w0c/pdb
• 関連するPDBエントリー: 1E7W 1E92
• 分子名称: PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4,6-TRIAMINOQUINAZOLINE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, enzyme inhibitor, pterin, short-chain reductase, leishmania, methotrexate, trypanosoma, nadp, methotrexate resistance
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 268699.73

構造登録者

Mcluskey, K.,Gibellini, F.,Carvalho, P.,Avery, M.,Hunter, W. (登録日: 2004-06-02, 公開日: 2004-09-30, 最終更新日: 2023-12-13)

• 主引用文献: Mcluskey, K.,Gibellini, F.,Carvalho, P.,Avery, M.,Hunter, W.; Inhibition of Leishmania Major Pteridine Reductase by 2,4,6-Triaminoquinazoline: Structure of the Nadph Ternary Complex; Acta Crystallogr.,Sect.D, 60:1780-, 2004; PubMed: 15388924; DOI: 10.1107/S0907444904018955

実験手法

X-RAY DIFFRACTION (2.6 Å)