1W0C
Inhibition of Leishmania major pteridine reductase (PTR1) by 2,4,6-triaminoquinazoline; structure of the NADP ternary complex.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | PTERIDINE REDUCTASE | polymer | 307 | 32647.0 | 8 | UniProt (Q01782) Pfam (PF13561) In PDB | LEISHMANIA MAJOR | H REGION METHOTREXATE RESISTANCE PROTEIN |
2 | A, B, C, D, E... | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 8 | Chemie (NAP) | |||
3 | A, B, C, D, E... | 2,4,6-TRIAMINOQUINAZOLINE | non-polymer | 175.2 | 9 | Chemie (TAQ) | |||
4 | water | water | 18.0 | 1117 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: -19 - -1 (PDB: 1W0C)
A, B, C, D, E, F, G, H: 1 - 288 (UniProt: Q01782)
A, B, C, D, E, F, G, H: 1 - 288 (UniProt: Q01782)
PDB | External Database | Details |
---|---|---|
Val 162 | Phe 162 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 261175.8 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 7524.0 | |
All* | Total formula weight | 268699.7 |