1VYQ
Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design
Summary for 1VYQ
Entry DOI | 10.2210/pdb1vyq/pdb |
Descriptor | DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, 2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE (3 entities in total) |
Functional Keywords | drug design, plasmodium falciparum, dutpase, deoxyuridine nucleotidohydrolase, malaria, hydrolase |
Biological source | PLASMODIUM FALCIPARUM |
Total number of polymer chains | 3 |
Total formula weight | 60227.05 |
Authors | Whittingham, J.L.,Leal, I.,Kasinathan, G.,Nguyen, C.,Bell, E.,Jones, A.F.,Berry, C.,Benito, A.,Turkenburg, J.P.,Dodson, E.J.,Ruiz Perez, L.M.,Wilkinson, A.J.,Johansson, N.G.,Brun, R.,Gilbert, I.H.,Gonzalez Pacanowska, D.,Wilson, K.S. (deposition date: 2004-05-05, release date: 2005-05-26, Last modification date: 2023-12-13) |
Primary citation | Whittingham, J.L.,Leal, I.,Nguyen, C.,Kasinathan, G.,Bell, E.,Jones, A.F.,Berry, C.,Benito, A.,Turkenburg, J.P.,Dodson, E.J.,Ruiz Perez, L.M.,Wilkinson, A.J.,Johansson, N.G.,Brun, R.,Gilbert, I.H.,Gonzalez Pacanowska, D.,Wilson, K.S. Dutpase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors. Structure, 13:329-, 2005 Cited by PubMed: 15698576DOI: 10.1016/J.STR.2004.11.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report