1VYJ

Structural and biochemical studies of human PCNA complexes provide the basis for association with CDK/cyclin and rationale for inhibitor design

1VYJ の概要

• エントリーDOI: 10.2210/pdb1vyj/pdb
• 関連するPDBエントリー: 1AXC 1U76 1U7B 1VYM 1W60
• 分子名称: PROLIFERATING CELL NUCLEAR ANTIGEN, SMALL PEPTIDE SAVLQKKITDYFHPKK (3 entities in total)
• 機能のキーワード: dna, replication, processivity, oncogene, dna-binding protein, dna replication, dna-binding systemic lupus erythematosus, dna binding protein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 184224.11

構造登録者

Kontopidis, G.,Wu, S.,Zheleva, D.,Taylor, P.,Mcinnes, C.,Lane, D.,Fischer, P.,Walkinshaw, M.D. (登録日: 2004-04-30, 公開日: 2005-01-13, 最終更新日: 2023-12-13)

• 主引用文献: Kontopidis, G.,Wu, S.,Zheleva, D.,Taylor, P.,Mcinnes, C.,Lane, D.,Fischer, P.,Walkinshaw, M.D.; Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design; Proc.Natl.Acad.Sci.USA, 102:1871-, 2005; PubMed: 15681588; DOI: 10.1073/PNAS.0406540102

実験手法

X-RAY DIFFRACTION (2.8 Å)