1VT6

Molecular structure of the octamer D(G-G-C-C-G-G-C-C) modified A-DNA

Summary for 1VT6

• Entry DOI: 10.2210/pdb1vt6/pdb
• Descriptor: DNA (5'-D(*GP*GP*CP*CP*GP*GP*CP*C)-3') (1 entity in total)
• Functional Keywords: a-dna, double helix, dna
• Total number of polymer chains: 1
• Total formula weight: 2428.59

Authors

Wang, A.H.-J.,Fujii, S.,Van Boom, J.H.,Rich, A. (deposition date: 1988-08-18, release date: 2011-07-13, Last modification date: 2023-12-27)

Primary citation

Wang, A.H.,Fujii, S.,van Boom, J.H.,Rich, A.
Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA.
Proc.Natl.Acad.Sci.USA, 79:3968-3972, 1982

PubMed Abstract: The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.

PubMed: 6955784

Experimental method

X-RAY DIFFRACTION (2.25 Å)