1VIN

BOVINE CYCLIN A3

1VIN の概要

• エントリーDOI: 10.2210/pdb1vin/pdb
• 分子名称: CYCLIN A (2 entities in total)
• 機能のキーワード: cyclin, cell cycle, kinase-regulatory-subunit, binding protein
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Nucleus: P30274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30831.50

構造登録者

Noble, M.E.M.,Endicott, J.A.E.,Brown, N.R. (登録日: 1996-03-15, 公開日: 1996-08-17, 最終更新日: 2024-02-14)

主引用文献

Brown, N.R.,Noble, M.E.,Endicott, J.A.,Garman, E.F.,Wakatsuki, S.,Mitchell, E.,Rasmussen, B.,Hunt, T.,Johnson, L.N.
The crystal structure of cyclin A.
Structure, 3:1235-1247, 1995

PubMed Abstract: Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs. Cyclins exhibit diverse sequences but all share homology over a region of approximately 100 amino acids, termed the cyclin box. From the determination of the structure of cyclin A, together with results from biochemical and genetic analyses, we can identify which parts of the cyclin molecular may contribute to cyclin A structure and function.

PubMed: 8591034
DOI: 10.1016/S0969-2126(01)00259-3

実験手法

X-RAY DIFFRACTION (2 Å)