1VCC

AMINO TERMINAL 9KDA DOMAIN OF VACCINIA VIRUS DNA TOPOISOMERASE I RESIDUES 1-77, EXPERIMENTAL ELECTRON DENSITY FOR RESIDUES 1-77

1VCC の概要

• エントリーDOI: 10.2210/pdb1vcc/pdb
• 分子名称: DNA TOPOISOMERASE I (2 entities in total)
• 機能のキーワード: dna binding
• 由来する生物種: Vaccinia virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9066.25

構造登録者

Sharma, A.,Hanai, R.,Mondragon, A. (登録日: 1995-10-02, 公開日: 1996-03-08, 最終更新日: 2024-02-14)

主引用文献

Sharma, A.,Hanai, R.,Mondragon, A.
Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution.
Structure, 2:767-777, 1994

PubMed Abstract: Vaccinia virus, a cytoplasmically-replicating poxvirus, encodes a type I DNA topoisomerase that is biochemically similar to eukaryotic-like DNA topoisomerases I, and which has been widely studied as a model topoisomerase. It is the smallest topoisomerase known and is unusual in that it is resistant to the potent chemotherapeutic agent camptothecin.

PubMed: 7994576
DOI: 10.1016/S0969-2126(94)00077-8

実験手法

X-RAY DIFFRACTION (1.6 Å)