1VCB

THE VHL-ELONGINC-ELONGINB STRUCTURE

1VCB の概要

• エントリーDOI: 10.2210/pdb1vcb/pdb
• 分子名称: PROTEIN (ELONGIN B), PROTEIN (ELONGIN C), PROTEIN (VHL), ... (4 entities in total)
• 機能のキーワード: tumor suppressor, cancer, ubiquitin, beta sandwich, transcription, transcriptional elongation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Probable): Q15370 Q15369; Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 176764.31

構造登録者

Stebbins, C.E.,Kaelin, W.G.,Pavletich, N.P. (登録日: 1999-03-13, 公開日: 1999-04-21, 最終更新日: 2023-12-27)

主引用文献

Stebbins, C.E.,Kaelin Jr., W.G.,Pavletich, N.P.
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Science, 284:455-461, 1999

PubMed Abstract: Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. The structure of the ternary complex at 2.7 angstrom resolution shows two interfaces, one between VHL and ElonginC and another between ElonginC and ElonginB. Tumorigenic mutations frequently occur in a 35-residue domain of VHL responsible for ElonginC binding. A mutational patch on a separate domain of VHL indicates a second macromolecular binding site. The structure extends the similarities to the SCF (Skp1-Cul1-F-box protein) complex that targets proteins for degradation, supporting the hypothesis that VHL may function in an analogous pathway.

PubMed: 10205047
DOI: 10.1126/science.284.5413.455

実験手法

X-RAY DIFFRACTION (2.7 Å)