1V0N

Xylanase Xyn10a from Streptomyces lividans in complex with xylobio-isofagomine at pH 7.5

1V0N の概要

• エントリーDOI: 10.2210/pdb1v0n/pdb
• 関連するPDBエントリー: 1E0V 1E0W 1E0X 1KNL 1KNM 1MC9 1OD8 1V0K 1V0L 1V0M 1XAS
• 分子名称: ENDO-1,4-BETA-XYLANASE A, 1,2-ETHANEDIOL, PIPERIDINE-3,4-DIOL, ... (6 entities in total)
• 機能のキーワード: glycoside hydrolase family 10, xylanase, xylan degradation, deoxynojirimycin, hydrolase
• 由来する生物種: STREPTOMYCES LIVIDANS
• 細胞内の位置: Secreted: P26514
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34589.95

構造登録者

Gloster, T.M.,Williams, S.J.,Roberts, S.,Tarling, C.A.,Wicki, J.,Withers, S.G.,Davies, G.J. (登録日: 2004-03-31, 公開日: 2004-08-16, 最終更新日: 2024-11-13)

主引用文献

Gloster, T.M.,Williams, S.J.,Roberts, S.,Tarling, C.A.,Wicki, J.,Withers, S.G.,Davies, G.J.
Atomic Resolution Analyses of the Binding of Xylobiose-Derived Deoxynojirimycin and Isofagomine to Xylanase Xyn10A
Chem.Commun.(Camb.), 16:1794-, 2004

PubMed Abstract: The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted (4)C(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

PubMed: 15306887
DOI: 10.1039/B405152A

実験手法

X-RAY DIFFRACTION (1.1 Å)