1UZ4

Common inhibition of beta-glucosidase and beta-mannosidase by isofagomine lactam reflects different conformational intineraries for glucoside and mannoside hydrolysis

Summary for 1UZ4

• Entry DOI: 10.2210/pdb1uz4/pdb
• Related: 1UUQ
• Descriptor: MAN5A, (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: mannosidase, inhibitor, isofagomaninelactam, hydrolase
• Biological source: CELLVIBRIO MIXTUS (CELLVIBRIO MIXTUS)
• Total number of polymer chains: 1
• Total formula weight: 50764.22

Authors

Vincent, F.,Davies, G.J. (deposition date: 2004-03-04, release date: 2004-11-03, Last modification date: 2023-12-13)

• Primary citation: Vincent, F.,Gloster, T.M.,Macdonald, J.,Morland, C.,Stick, R.V.,Dias, F.,Prates, J.,Fontes, C.M.G.A.,Gilbert, H.J.,Davies, G.J.; Common Inhibition of Both Beta-Glucosidases and Beta-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis; Chembiochem, 5:1596-, 2004; PubMed: 15515081; DOI: 10.1002/CBIC.200400169

Experimental method

X-RAY DIFFRACTION (1.71 Å)