1UYJ

Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin

Summary for 1UYJ

• Entry DOI: 10.2210/pdb1uyj/pdb
• Descriptor: EPSILON-TOXIN, URANIUM ATOM (3 entities in total)
• Functional Keywords: toxin, beta pore forming toxin
• Biological source: CLOSTRIDIUM PERFRINGENS
• Total number of polymer chains: 3
• Total formula weight: 101903.73

Authors

Cole, A.R.,Gibert, M.,Poppoff, M.,Moss, D.S.,Titball, R.W.,Basak, A.K. (deposition date: 2004-03-02, release date: 2004-08-05, Last modification date: 2024-05-08)

Primary citation

Cole, A.R.,Gibert, M.,Popoff, M.,Moss, D.S.,Titball, R.W.,Basak, A.K.
Clostridium Perfringens Epsilon-Toxin Shows Structural Similarity to the Pore-Forming Toxin Aerolysin
Nat.Struct.Mol.Biol., 11:797-, 2004

PubMed Abstract: Epsilon-toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.

PubMed: 15258571
DOI: 10.1038/NSMB804

Experimental method

X-RAY DIFFRACTION (2.6 Å)