1UWO

CALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES

Summary for 1UWO

• Entry DOI: 10.2210/pdb1uwo/pdb
• NMR Information: BMRB: 5206,5377
• Descriptor: S100B (1 entity in total)
• Functional Keywords: human s100b, calcium-binding protein, ef-hand, conformational change, solution structure
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P04271
• Total number of polymer chains: 2
• Total formula weight: 21191.68

Authors

Smith, S.P.,Shaw, G.S. (deposition date: 1997-12-05, release date: 1998-06-10, Last modification date: 2024-05-22)

Primary citation

Smith, S.P.,Shaw, G.S.
A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form.
Structure, 6:211-222, 1998

PubMed Abstract: S100B is a homodimeric member of the EF-hand calcium-binding protein superfamily. The protein has been implicated in cellular processes such as cell differentiation and growth, plays a role in cytoskeletal structure and function, and may have a role in neuropathological diseases, such as Alzheimers. The effects of S100B are mediated via its interaction with target proteins. While several studies have suggested that this interaction is propagated through a calcium-induced conformational change, leading to the exposure of a hydrophobic region of S100B, the molecular details behind this structural alteration remain unclear.

PubMed: 9519411
DOI: 10.1016/S0969-2126(98)00022-7

Experimental method

SOLUTION NMR