1UUP
Crystal Structure of A Dimeric Form of Streptococcal Pyrogenic Exotoxin A (SpeA1).
Summary for 1UUP
| Entry DOI | 10.2210/pdb1uup/pdb |
| Related | 1B1Z 1FNU 1FNV 1FNW 1HA5 1L0X 1L0Y |
| Descriptor | EXOTOXIN TYPE A, ZINC ION (3 entities in total) |
| Functional Keywords | toxin, molecular recognition, superantigen, exotoxin, zinc binding, dimer |
| Biological source | STREPTOCOCCUS PYOGENES |
| Total number of polymer chains | 4 |
| Total formula weight | 103541.62 |
| Authors | Baker, M.D.,Gendlina, I.,Collins, C.M.,Acharya, K.R. (deposition date: 2004-01-08, release date: 2004-08-12, Last modification date: 2024-11-06) |
| Primary citation | Baker, M.D.,Gendlina, I.,Collins, C.M.,Acharya, K.R. Crystal Structure of a Dimeric Form of Streptococcal Pyrogenic Exotoxin a (Spea1) Protein Sci., 13:2285-, 2004 Cited by PubMed Abstract: Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous work suggested that the dimer results from an intermolecular disulfide bond between the cysteines at positions 90 of each monomer. Here, we present the crystal structure of the dimeric form of SpeA1. The toxin crystallizes in the orthorhombic space group P212121, with two dimers in the crystallographic asymmetric unit. The final structure has a crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water molecules, and 4 zinc atoms (one zinc atom per molecule). The implications of SpeA1 dimer on MHC class II and T-cell receptor recognition are discussed. PubMed: 15295110DOI: 10.1110/PS.04826804 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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