1UTS

Designed HIV-1 TAR Binding Ligand

Summary for 1UTS

• Entry DOI: 10.2210/pdb1uts/pdb
• Related: 1UUD 1UUI
• Descriptor: RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(3-AMINOPROPOXY)-5-(1H-INDOL-5-YL)BENZYL]-N-(2-PIPERAZIN-1-YLETHYL)AMINE (2 entities in total)
• Functional Keywords: hiv-1, tar rna, drug design, antiviral, ligand binding, conformational change
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1 (HIV-1)
• Total number of polymer chains: 1
• Total formula weight: 9715.11

Authors

Davis, B.,Murchie, A.I.H.,Aboul-Ela, F.,Karn, J. (deposition date: 2003-12-10, release date: 2004-02-12, Last modification date: 2021-05-05)

• Primary citation: Murchie, A.I.,Davis, B.,Isel, C.,Afshar, M.,Drysdale, M.J.,Bower, J.,Potter, A.J.,Starkey, I.D.,Swarbrick, T.M.,Mirza, S.,Prescott, C.D.,Vaglio, P.,Aboul-ela, F.,Karn, J.; Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.; J.Mol.Biol., 336:625-638, 2004; PubMed: 15095977; DOI: 10.1016/j.jmb.2003.12.028

Experimental method

SOLUTION NMR