1UTR
UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Summary for 1UTR
| Entry DOI | 10.2210/pdb1utr/pdb |
| Descriptor | UTEROGLOBIN, 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL (2 entities in total) |
| Functional Keywords | uteroglobin, clara cell 17 kda protein (cc10), phospholipase a2 inhibitor, clara cell phospholipid-binding protein, progesterone binding, mammalian pcb-binding protein |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Secreted: P17559 |
| Total number of polymer chains | 2 |
| Total formula weight | 21362.58 |
| Authors | Hard, T.,Barnes, H.J.,Larsson, C.,Gustafsson, J.-A.,Lund, J. (deposition date: 1995-09-01, release date: 1995-12-07, Last modification date: 2024-05-22) |
| Primary citation | Hard, T.,Barnes, H.J.,Larsson, C.,Gustafsson, J.A.,Lund, J. Solution structure of a mammalian PCB-binding protein in complex with a PCB. Nat.Struct.Biol., 2:983-989, 1995 Cited by PubMed Abstract: Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand. PubMed: 7583672DOI: 10.1038/nsb1195-983 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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