1UPI

Mycobacterium tuberculosis rmlC epimerase (Rv3465)

1UPI の概要

• エントリーDOI: 10.2210/pdb1upi/pdb
• 分子名称: DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (2 entities in total)
• 機能のキーワード: epimerase, rhamnose pathway, psi, protein structure initiative, tb structural genomics consortium, tb, tbsgc
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24903.82

構造登録者

Kim, C.-Y.,Naranjo, C.,Waldo, G.S.,Lekin, T.,Segelke, B.W.,Kantardjieff, K.A.,Zemla, A.,Terwilliger, T.,Rupp, B.,TB Structural Genomics Consortium (TBSGC) (登録日: 2003-10-05, 公開日: 2003-10-07, 最終更新日: 2024-10-16)

主引用文献

Kantardjieff, K.A.,Kim, C.-Y.,Naranjo, C.,Waldo, G.S.,Lekin, T.,Segelke, B.W.,Zemla, A.,Park, M.S.,Terwilliger, T.,Rupp, B.
Mycobacterium Tuberculosis Rmlc Epimerase (Rv3465): A Promising Drug-Target Structure in the Rhamnose Pathway
Acta Crystallogr.,Sect.D, 60:895-, 2004

PubMed Abstract: The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial cell-wall synthesis. Because it is structurally unique, highly substrate-specific and does not require a cofactor, RmlC is considered to be the most promising drug target in the pathway, and the M. tuberculosis rmlC gene was selected in the initial round of TB Structural Genomics Consortium targets for structure determination. The 1.7 A native structure determined by the consortium facilities is reported and implications for in silico screening of ligands for structure-guided drug design are discussed.

PubMed: 15103135
DOI: 10.1107/S0907444904005323

実験手法

X-RAY DIFFRACTION (1.7 Å)