1UK1
Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor
Summary for 1UK1
Entry DOI | 10.2210/pdb1uk1/pdb |
Related | 1UK0 |
Descriptor | Poly [ADP-ribose] polymerase-1, 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P09874 |
Total number of polymer chains | 2 |
Total formula weight | 79180.63 |
Authors | Kinoshita, T. (deposition date: 2003-08-14, release date: 2004-09-14, Last modification date: 2023-12-27) |
Primary citation | Hattori, K.,Kido, Y.,Yamamoto, H.,Ishida, J.,Kamijo, K.,Murano, K.,Ohkubo, M.,Kinoshita, T.,Iwashita, A.,Mihara, K.,Yamazaki, S.,Matsuoka, N.,Teramura, Y.,Miyake, H. Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase J.Med.Chem., 47:4151-4154, 2004 Cited by PubMed: 15293985DOI: 10.1021/jm0499256 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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