1UDU

Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)

Summary for 1UDU

• Entry DOI: 10.2210/pdb1udu/pdb
• Related: 1UDT
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: cgmp-specific phosphodiesterase 5, tadalafil, selective inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 76018.85

Authors

Sung, B.-J.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Lee, T.G.,Cho, J.M.,Park, S.-Y.,Lee, J.-O.,Jeon, Y.H.,Hwang, K.Y.,Ro, S. (deposition date: 2003-05-06, release date: 2004-05-11, Last modification date: 2023-12-27)

• Primary citation: Sung, B.-J.,Hwang, K.Y.,Jeon, Y.H.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Park, S.-Y.,Lee, J.-O.,Lee, T.G.,Ro, S.,Cho, J.M.; Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules; Nature, 425:98-102, 2003; PubMed: 12955149; DOI: 10.1038/nature01914

Experimental method

X-RAY DIFFRACTION (2.83 Å)