1U8G
Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2
Summary for 1U8G
Entry DOI | 10.2210/pdb1u8g/pdb |
Related | 1NH0 |
Related PRD ID | PRD_000401 |
Descriptor | PROTEASE RETROPEPSIN, peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2 (3 entities in total) |
Functional Keywords | aspartyl protease, human immunodeficiency virus, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 3 |
Total formula weight | 22340.27 |
Authors | Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Hradilek, M.,Soucek, R.,Stouracova, R.,Konvalinka, J.,Sedlacek, J. (deposition date: 2004-08-06, release date: 2004-11-02, Last modification date: 2018-02-14) |
Primary citation | Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Stouracova, R.,Soucek, M.,Hradilek, M.,Konvalinka, J.,Sedlacek, J. Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex. Acta Crystallogr.,Sect.D, 60:1943-1948, 2004 Cited by PubMed: 15502300DOI: 10.1107/S0907444904021572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.201 Å) |
Structure validation
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