1U74

Electron Transfer Complex between cytochrome C and cytochrome C peroxidase

1U74 の概要

• エントリーDOI: 10.2210/pdb1u74/pdb
• 分子名称: cytochrome c peroxidase, Cytochrome c iso-1, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: protein-protein complex, heme, oxidoreductase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Mitochondrion matrix: P00431; Mitochondrion intermembrane space: P00044
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94329.77

構造登録者

Crane, B.R.,Kang, S.A. (登録日: 2004-08-02, 公開日: 2004-09-28, 最終更新日: 2024-02-14)

主引用文献

Kang, S.A.,Marjavaara, P.J.,Crane, B.R.
Electron transfer between cytochrome c and cytochome c peroxidase in single crystals.
J.Am.Chem.Soc., 126:10836-10837, 2004

PubMed Abstract: Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form an important redox pair for understanding interprotein electron transfer (ET). Measurements of ET rates from photoexcited CcP substituted with Zn porphyrin to either yeast Fe(III)Cc or horse Fe(III)Cc in crystals reveal that the molecular associations found in the respective crystal structures determine solution reactivity. Similar forward rates for yeast isozyme-1 Cc (yCc) and yCc homologue horse Cc (hCc), despite different orientations relative to CcP, suggest small-amplitude conformational gating of ET even in the crystalline state; faster back ET in the yCc compared to the hCc complex agrees with the relative coupling between redox sites predicted by the structures.

PubMed: 15339156
DOI: 10.1021/ja049230u

実験手法

X-RAY DIFFRACTION (2.4 Å)